If you are self publishing because you just can't handle the rejection, then you need to reconsider. Why? Because any rejection you can possibly get is not going to be near as bad as some of the reviews you'll get once you're published out there. And trust me. If you write long enough, there will be that one person (or more!) who like to pound nails into your heart by writing how horrible your work is. And they will not hold back. AT. ALL.
So how do you differentiate between just being tired of rejections to not being able to handle rejections? First, what is your reaction to a rejection? If your primary response is anger, then it's probably a sign that you aren't equipped to handle a rejection yet. That's not to say that you will never be but just imagine that rejection coupled with a detailed look at everything that is wrong with your novel. If you are getting angry at a single rejection, what would you do with a negative review? And if you retaliate with either, you end up looking like an unprofessional fool; the exact opposite of what you are trying to accomplish.
So really take stock of why you're self publishing before you actually do it. It's a heavy commitment and if you aren't doing it for the right reasons, you will fail. If you take every rejection personally, then you will likely take negative reviews personally, too.
I understand that it's hard not to take it personally, even for those of us who have been doing this a long time. How you react to it is the key here.
Best wishes to all of you.